abstract：:The main risk factor for primary open-angle glaucoma (POAG) is increased intraocular pressure (IOP). It is of interest that about half of the patients have an IOP within the normal range (normal-tension glaucoma, NTG). Additionally, there is a group of patients with a high IOP but no glaucomatous neurodegeneration (oc...

journal_title：Journal of clinical medicine

authors： Langbøl M,Saruhanian S,Baskaran T,Tiedemann D,Mouhammad ZA,Toft-Kehler AK,Jun B,Vohra R,Bazan NG,Kolko M

更新日期：2020-09-15 00:00:00

abstract：:The repurposing of colchicine for the treatment of COVID-19 was suggested based in its immunomodulatory, anti-inflammatory, and anti-viral properties. We performed a single-center propensity score matched cohort study, including all consecutive COVID-19 patients admitted to a community hospital between 1 March 2020 an...

journal_title：Journal of clinical medicine

authors： Brunetti L,Diawara O,Tsai A,Firestein BL,Nahass RG,Poiani G,Schlesinger N

更新日期：2020-09-14 00:00:00

abstract：BACKGROUND:The National Academies of Science have issued a call for zero preventable trauma deaths. The mortality characteristics in all patients with aortic injury are not well described. METHODS:All prehospital and hospital medical examiner records for deaths occurring in Harris County, Texas in 2014 were retrospect...

journal_title：Journal of clinical medicine

authors： Chang R,Drake SA,Holcomb JB,Phillips G,Wade CE,Charlton-Ouw KM

更新日期：2020-09-14 00:00:00

abstract：:Limited data are available regarding optimal treatment for refractory Mycobacterium avium complex-pulmonary disease (MAC-PD). We evaluated outcomes of inhaled amikacin (AMK) with clofazimine (CFZ) regimens as an add-on salvage therapy for refractory MAC-PD. We retrospectively analyzed 52 patients with refractory MAC-P...

journal_title：Journal of clinical medicine

authors： Kim BG,Kim H,Kwon OJ,Huh HJ,Lee NY,Baek SY,Sohn I,Jhun BW

更新日期：2020-09-14 00:00:00

abstract：:The purpose of this study is to describe the Minimally Invasive Intraoral Approach (MIIA) performed on selected cases of abscesses and neck phlegmons of odontogenic origin when the infection has not spread beyond the inferior mandibular margin. This technique allows us to avoid cervicotomy by a direct approach to the ...

journal_title：Journal of clinical medicine

authors： Galli M,Fusconi M,Federici FR,Candelori F,De Vincentiis M,Polimeni A,Testarelli L,Cassese B,Miccoli G,Greco A

更新日期：2020-09-14 00:00:00

abstract：:Non-steroidal anti-inflammatory drugs (NSAIDs) can be used as opioid alternatives for patient-controlled analgesia (PCA). However, their use after nephrectomy has raised concerns regarding possible nephrotoxicity. This study compared postoperative renal function and postoperative outcomes between patients using NSAID ...

journal_title：Journal of clinical medicine

authors： Han J,Jeon YT,Oh AY,Koo CH,Bae YK,Ryu JH

更新日期：2020-09-13 00:00:00

abstract：:The ongoing coronavirus disease 2019 (COVID-19) pandemic has resulted in efforts to identify therapies to ameliorate adverse clinical outcomes. The recognition of the key role for increased inflammation in COVID-19 has led to a proliferation of clinical trials targeting inflammation. The purpose of this review is to c...

journal_title：Journal of clinical medicine

authors： Campbell CM,Guha A,Haque T,Neilan TG,Addison D

更新日期：2020-09-11 00:00:00

abstract：:The causes of disordered sleep, frequently reported by patients with inflammatory bowel diseases (IBD), are poorly understood. The study aimed to evaluate sleep quality in IBD patients and to identify factors affecting their sleep. IBD patients (n = 133) and healthy controls (HC; n = 57) were included in the study and...

journal_title：Journal of clinical medicine

authors： Sochal M,Małecka-Panas E,Gabryelska A,Talar-Wojnarowska R,Szmyd B,Krzywdzińska M,Białasiewicz P

更新日期：2020-09-10 00:00:00

abstract：:(1) Background: Intravitreal anti-vascular endothelial growth factor (anti-VEGF) is an established treatment for center-involving diabetic macular edema (ci-DME). However, the clinical response is heterogeneous. This study investigated miRNAs as a biomarker to predict treatment response to anti-VEGF in DME. (2) Method...

journal_title：Journal of clinical medicine

authors： Chan HW,Yang B,Wong W,Blakeley P,Seah I,Tan QSW,Wang H,Bhargava M,Lin HA,Chai CH,Mangunkusumo EA,Thet N,Yuen YS,Sethi R,Wang S,Hunziker W,Lingam G,Su X

更新日期：2020-09-10 00:00:00

abstract：:We aimed to explore the accuracy of physical examination (PE) to detect the synovial and extra-synovial pathologies in psoriatic arthritis (PsA) in comparison to ultrasonography (US). Twenty-nine PsA patients with hand pain were included in the study. A detailed PE of the hands was performed and US scans were performe...

journal_title：Journal of clinical medicine

authors： Gazel U,Solmaz D,Ayan G,Ivory C,Karsh J,Aydin SZ

更新日期：2020-09-10 00:00:00

abstract：BACKGROUND AND AIMS:Data from clinical trials suggest that biological drugs may improve the outcomes in Crohn's disease (CD) by reducing the need for surgery or hospitalization. The aim of this study is to evaluate the time-trends of the use of biological drugs and other treatments for CD, and its relationship with out...

journal_title：Journal of clinical medicine

authors： Brunet E,Vela E,Melcarne L,Clèries M,Pontes C,Llovet LP,García-Iglesias P,Gallach M,Villòria A,Vergara M,Calvet X

更新日期：2020-09-08 00:00:00

abstract：:Mesalamine (5-ASA) is the mainstay therapy in patients with mild-to-moderate active ulcerative colitis (UC). However, non-adherence to therapy and practice variability among gastroenterologists represent long-standing barriers, leading to poor outcomes. Additionally, targets to treat in UC are increasingly evolving fr...

journal_title：Journal of clinical medicine

authors： Solitano V,D'Amico F,Fiorino G,Paridaens K,Peyrin-Biroulet L,Danese S

更新日期：2020-09-08 00:00:00

abstract：:This article presents the technical aspects of the Polish fetal cardiac interventions (FCI) program, including preparation of the team and modifications in the technique of the procedure that aim to increase its safety for the mother and the fetus. Over 9 years, 128 FCI in 113 fetuses have been performed: 94 balloon a...

journal_title：Journal of clinical medicine

authors： Debska M,Kolesnik A,Rebizant B,Sekowska A,Grzyb A,Chaberek K,Witwicki J,Debski R,Dangel J

更新日期：2020-09-07 00:00:00

abstract：:There are considerable psychological and psychiatric consequences of the pandemic. Researchers have started to take into account the real or perceived sense of social threats that may be expressed, such as anxiety, depression, and sleep disorders. However, analyses on pandemic-related anxiety, depression, and sleep di...

journal_title：Journal of clinical medicine

authors： Wańkowicz P,Szylińska A,Rotter I

更新日期：2020-09-05 00:00:00

abstract：:Atopic dermatitis (AD) is characterized by chronic, relapsing, pruritic skin inflammation and does not have a well-understood pathogenesis. In this study, we addressed the contribution of adipokines to AD eczema based on the assessment of blood levels of adiponectin, resistin, leptin, lipocalin-2, and vaspin in adult ...

journal_title：Journal of clinical medicine

authors： Jaworek AK,Szepietowski JC,Szafraniec K,Jaworek M,Hałubiec P,Wojas-Pelc A,Pokorski M

更新日期：2020-09-04 00:00:00

abstract：:Decompensated cirrhosis predisposes to infectious diseases and acute-on-chronic liver failure (ACLF) in critically ill patients. Infections like spontaneous bacterial peritonitis (SBP) are frequently associated with multi-organ failure and increased mortality. Consequently, reliable predictors of outcome and early dia...

journal_title：Journal of clinical medicine

authors： Mayr U,Lukas M,Elnegouly M,Vogt C,Bauer U,Ulrich J,Schmid RM,Huber W,Lahmer T

更新日期：2020-09-04 00:00:00

abstract：:Age-related macular degeneration is the leading cause of blindness in the developed world. Since advanced glycation end products (AGEs) are implicated in the pathogenesis of AMD through various lines of evidence, we investigated the potential of fructosamine-3-kinase (FN3K) in the disruption of retinal AGEs, drusenoid...

journal_title：Journal of clinical medicine

authors： De Bruyne S,Van den Broecke C,Vrielinck H,Khelifi S,De Wever O,Bracke K,Huizing M,Boston N,Himpe J,Speeckaert M,Vral A,Van Dorpe J,Van Aken E,Delanghe JR

更新日期：2020-09-04 00:00:00

abstract：:The aim was to perform a translation, cross-cultural adaptation, and psychometric evaluation of the Spanish version of the Tampa Scale of Kinesiophobia for Temporomandibular Disorders (TSK-TMD-S). The study sample included 110 patients with TMD. We translated and cross-culturally adapted the TSK-TMD-S using standard m...

journal_title：Journal of clinical medicine

authors： La Touche R,Pardo-Montero J,Cuenca-Martínez F,Visscher CM,Paris-Alemany A,López-de-Uralde-Villanueva I

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:To investigate the value of visual acuity and patient-perceived visual function test when subretinal drusenoid deposits (SDD) are incorporated into the classification of age-related macular degeneration (AMD). A total of 50 participants were recruited into the study in these groups: healthy ageing (n = 11), int...

journal_title：Journal of clinical medicine

authors： Grewal MK,Chandra S,Gurudas S,Bird A,Jeffery G,Sivaprasad S

更新日期：2020-09-01 00:00:00

abstract：:This study explored the perspectives and experiences of breast cancer patients and medical oncologists with regards to participation in a lifestyle intervention at a tertiary cancer treatment center. A thematic approach was used to understand the context within which a lifestyle intervention was recommended and experi...

journal_title：Journal of clinical medicine

authors： Balneaves LG,Truant TLO,Van Patten C,Kirkham AA,Waters E,Campbell KL

更新日期：2020-08-31 00:00:00

abstract：:We prospectively evaluated the relationship between meibomian gland dysfunction (MGD) and Graves' ophthalmopathy (GO) in 19 patients (38 eyes) with subjective dry eye symptoms, compared to 14 age-matched normal participants (14 eyes). Extraocular muscle and lacrimal gland enlargement were evaluated by magnetic resonan...

journal_title：Journal of clinical medicine

authors： Inoue S,Kawashima M,Arita R,Kozaki A,Tsubota K

更新日期：2020-08-31 00:00:00

abstract：:Graves' orbitopathy (GO) is the most common extrathyroidal manifestation of Graves' disease (GD). Our aim was to assess the efficacy and safety of Tocilizumab (TCZ) in GO refractory to conventional therapy. This was an open-label multicenter study of glucocorticoid-resistant GO treated with TCZ. The main outcomes were...

journal_title：Journal of clinical medicine

authors： Sánchez-Bilbao L,Martínez-López D,Revenga M,López-Vázquez Á,Valls-Pascual E,Atienza-Mateo B,Valls-Espinosa B,Maiz-Alonso O,Blanco A,Torre-Salaberri I,Rodríguez-Méndez V,García-Aparicio Á,Veroz-González R,Jovaní V,Peiteado D,

更新日期：2020-08-31 00:00:00

abstract：:Additive manufacturing (AM) of patient-specific implants (PSIs) is gradually moving towards in-house or point-of-care (POC) manufacturing. Polyetheretherketone (PEEK) has been used in cranioplasty cases as a reliable alternative to other alloplastic materials. As only a few fused filament fabrication (FFF) printers ar...

journal_title：Journal of clinical medicine

authors： Sharma N,Aghlmandi S,Cao S,Kunz C,Honigmann P,Thieringer FM

更新日期：2020-08-31 00:00:00

abstract：:A major challenge of cell-based therapy for cartilage lesions is the preservation of the chondrogenic phenotype during ex vivo cell cultivation. In this in vitro study, the chondro-inductive capacity of two different hyaline cartilage-conditioned cell culture media on human chondrocytes in 3D spheroids was determined....

journal_title：Journal of clinical medicine

authors： Klinder A,Kussauer S,Hiemer B,Wree A,Bader R,Jonitz-Heincke A

更新日期：2020-08-30 00:00:00

abstract：:It has been widely underlined that both gynaecological malignancies and urogynaecological disorders are often associated with high stress and have a negative impact on the quality of life and psychological well-being of women affected. Knowledge of the pelvic anatomy is crucial in recommending and carrying out the lea...

journal_title：Journal of clinical medicine

authors： Ziętek-Strobl A,Futyma K,Kuna-Broniowska I,Wojtaś M,Rechberger T

更新日期：2020-08-30 00:00:00

abstract：:To assess neck disability with respect to jaw disability, craniocervical position, cervical alignment, and sensorimotor impairments in patients with temporomandibular disorders (TMD), a systematic review and meta-analysis of observational studies trials were conducted. The meta-analysis showed statistically significan...

journal_title：Journal of clinical medicine

authors： Cuenca-Martínez F,Herranz-Gómez A,Madroñero-Miguel B,Reina-Varona Á,La Touche R,Angulo-Díaz-Parreño S,Pardo-Montero J,Del Corral T,López-de-Uralde-Villanueva I

更新日期：2020-08-30 00:00:00

abstract：BACKGROUND:Hyponatraemia is associated with increased morbidity, increased mortality and is frequently hospital-acquired due to inappropriate administration of hypotonic fluids. Despite several attempts to minimise the risk, knowledge is lacking as to whether inappropriate prescribing practice continues to be a concern...

journal_title：Journal of clinical medicine

authors： Sindahl P,Overgaard-Steensen C,Wallach-Kildemoes H,De Bruin ML,Leufkens HG,Kemp K,Gardarsdottir H

更新日期：2020-08-29 00:00:00

abstract：:Postoperative complications after pancreatic surgery are still a significant problem in clinical practice. The aim of this study was to characterize and compare the microbiomes of different body compartments (bile duct, duodenal mucosa, pancreatic tumor lesion, postoperative drainage fluid, and stool samples; preopera...

journal_title：Journal of clinical medicine

authors： Langheinrich M,Wirtz S,Kneis B,Gittler MM,Tyc O,Schierwagen R,Brunner M,Krautz C,Weber GF,Pilarsky C,Trebicka J,Agaimy A,Grützmann R,Kersting S

更新日期：2020-08-28 00:00:00

abstract：:(1) Background: L-arginine is a complex modulator of immune functions, and its levels are known to decrease under septic conditions. L-arginine may suppress leukocyte recruitment in vivo; however, little is known about the gestational age-specific effects of L-arginine on leukocyte recruitment in preterm infants. We n...

journal_title：Journal of clinical medicine

authors： Fitterer R,Lajqi T,Kranig SA,Braun M,Theissig N,Kuss N,Pöschl J,Frommhold D,Hudalla H

更新日期：2020-08-27 00:00:00

abstract：:Coronavirus disease 2019 (COVID-19) is a pandemic viral disease originated in Wuhan, China, in December 2019, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The severe form of the disease is often associated with acute respiratory distress syndrome (ARDS), and most critically ill patients ...

journal_title：Journal of clinical medicine

authors： Gardin C,Ferroni L,Chachques JC,Zavan B

更新日期：2020-08-26 00:00:00

abstract：:Von Hippel-Lindau (VHL), is a rare autosomal dominant inherited cancer in which the lack of VHL protein triggers the development of multisystemic tumors such us retinal hemangioblastomas (HB), CNS-HB, and clear cell renal cell carcinoma (ccRCC). ccRCC ranks third in terms of incidence and first in cause of death. Stan...

journal_title：Journal of clinical medicine

authors： Albiñana V,Gallardo-Vara E,de Rojas-P I,Recio-Poveda L,Aguado T,Canto-Cano A,Aguirre DT,Serra MM,González-Peramato P,Martínez-Piñeiro L,Cuesta AM,Botella LM

更新日期：2020-08-25 00:00:00

abstract：:One in every four deaths is due to cancer in Europe. In view of its increasing incidence, cancer became the leading cause of death and disease burden in Denmark, France, the Netherlands, and the UK. Without essential improvements in cancer prevention, an additional 775,000 cases of annual incidence have been prognosed...

journal_title：Journal of clinical medicine

authors： Liskova A,Samec M,Koklesova L,Giordano FA,Kubatka P,Golubnitschaja O

更新日期：2020-08-25 00:00:00

abstract：:Survivors of colorectal cancer (CRC) may experience a range of physical, psychosocial, and practical challenges as a consequence of their diagnosis. We assessed the patterns and documented content of follow-up visits within the first three years following treatment, in comparison to survivorship care guidelines. Survi...

journal_title：Journal of clinical medicine

authors： Garwood V,Lisy K,Jefford M

更新日期：2020-08-24 00:00:00

abstract：:We aimed to determine if low body weight (LBW) status (<50 kg) is independently associated with increased risk of ischemic stroke and bleeding in Thai patients with non-valvular atrial fibrillation (NVAF). (1) Background: It has been unclear whether LBW influence clinical outcome of patients with NVAF. (2) Methods: Th...

journal_title：Journal of clinical medicine

authors： Krittayaphong R,Chichareon P,Komoltri C,Kornbongkotmas S,Yindeengam A,Lip GYH

更新日期：2020-08-22 00:00:00

abstract：:The aim of this study was to elucidate the lifelong disease progression of chronic obstructive pulmonary disease (COPD) with biomarker changes and identify their influencing factors, by utilizing a new analysis method, Statistical Restoration of Fragmented Time-course (SReFT). Individual patient data (n = 1025) partic...

journal_title：Journal of clinical medicine

authors： Kawamatsu S,Jin R,Araki S,Yoshioka H,Sato H,Sato Y,Hisaka A

更新日期：2020-08-18 00:00:00

abstract：BACKGROUND:The long-term stability after soft tissue graft for covering gingival recession remains a pivotal goal for both patient and periodontist. Therefore, the aim of this study was to compare the four-year outcomes of the coronally advanced flap (CAF) versus the pouch/tunnel (POT) technique, both combined with con...

journal_title：Journal of clinical medicine

authors： Salem S,Salhi L,Seidel L,Lecloux G,Rompen E,Lambert F

更新日期：2020-08-14 00:00:00

abstract：:COVID-19 has catastrophically affected the world's panoramic view of human well-being in terms of healthcare and management. With the increase in the number of cases worldwide, neurological symptoms and psychological illnesses from COVID-19 have increasingly upsurged. Mental health illness and affective disorders, inc...

journal_title：Journal of clinical medicine

authors： Nami M,Gadad BS,Chong L,Ghumman U,Misra A,Gadad SS,Kumar D,Perry G,Abraham SJK,Rao KS

更新日期：2020-08-13 00:00:00

abstract：:Pancreatic pathology, comprising acute and chronic pancreatitis, autoimmune pancreatitis and pancreatic neoplasms, primarily presents with gastrointestinal symptoms and signs; however, it is well recognized that it can also associate a wide range of extra-digestive features. Among these systemic manifestations, cutane...

journal_title：Journal of clinical medicine

authors： Miulescu R,Balaban DV,Sandru F,Jinga M

更新日期：2020-08-12 00:00:00

abstract：BACKGROUND:Although extracorporeal membrane oxygenation (ECMO) is used for hemodynamic support for in-hospital cardiac arrest (IHCA) complicating acute myocardial infarction (AMI), there are limited data on the outcomes stratified by the timing of initiation of this strategy. METHODS:Adult (>18 years) AMI admissions w...

journal_title：Journal of clinical medicine

authors： Vallabhajosyula S,Patlolla SH,Bell MR,Cheungpasitporn W,Stulak JM,Schears GJ,Barsness GW,Holmes DR

更新日期：2020-08-12 00:00:00

abstract：BACKGROUND:To compare the clinical, serological and histologic features between male and female patients with Sjögren's syndrome (SS) and explore the potential effect of gender on lymphoma development. METHODS:From a multicenter population (Universities of Udine, Pisa and Athens, Harokopion and Ioannina (UPAHI)) consi...

journal_title：Journal of clinical medicine

authors： Chatzis L,Pezoulas VC,Ferro F,Gandolfo S,Donati V,Binutti M,Callegher SZ,Venetsanopoulou A,Zampeli E,Mavrommati M,Argyropoulou OD,Michalopoulos G,Voulgari PV,Exarchos T,Baldini C,Skopouli FN,Fotiadis DI,De Vita S,Mout

更新日期：2020-08-12 00:00:00